The plant does not produce the opioid alkaloid 7ohm, instead it is converted through oxidation to a small degree by the plant, and on a larger scale by our intestines and liver. It is now thought that the majority of the opioid effect from Kratom comes from oxidation of Mitragynine into 7ohm by cyp enzymes in our body. It turns out that high concentrations block opioid activity at mu and moderate to lower levels like that found in red strains might allow for the optimal amount of conversion of Mitragynine to 7ohm.
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